上海市免疫学研究所SvetoslavChakarov课题组招聘启事简

课题组长介绍

Svetoslav Chakarov研究员，博士生导师，上海交通大学医学院/上海市免疫学研究所课题组长。2013年博士毕业于法国图卢兹第三大学（University Paul Sabatier, Toulouse, France）免疫学专业，2014年至2019年在新加坡免疫学联网Florent Ginhoux课题组从事博士后研究，并于2019年以第一作者在Science杂志发表重要研究成果。2019-2020年任职新加坡免疫学网高级研究员。2021年作为海外高层次人才和上海高校特聘教授（东方学者）引进加盟上海交通大学医学院/上海市免疫学研究所并担任“髓系细胞生物学与代谢”课题组组长。2021年获得上海市科委外国专家项目，2022年入选国家自然科学基金优青（海外）项目，2023年作为项目骨干参与科技部重点专项“病原学与防疫技术体系研究”，2024年获得国家自然科学基金面上项目资助。

课题组主要研究方向

课题组主要集中于研究巨噬细胞异质性对肥胖和代谢性疾病的影响；嗜酸性粒细胞在代谢性疾病中与周围环境的相互作用；以生信分析为工具，整合单细胞 RNA-seq、单细胞 ATAC-seq、单细胞蛋白表达和高维空间成像。课题组采用前沿的跨学科研究方法，旨在了解肥胖和/或代谢疾病期间小鼠和人类先天免疫细胞/基质细胞的相互作用。使用多种新型诱导转基因和基因靶向小鼠模型，基因组测序分析，Single-cell RNA-seq, Single-cell ATAC-seq, Mass Cytometry (CyTOF), “InfinityFlow” pipeline, Imaging Mass Cytometry (IMC) 和Co-detection by indexing (CODEX)。在Science, PNAS, Immunity, Journal of Experimental Medicine等国际学术期刊发表研究论文。现因课题组研究需要，诚聘研究助理1名，博士后2名。实验室致力营造平等友爱的工作环境，严谨认真的科研氛围，欢迎兴趣相投的人才与实验室共同成长。

招聘岗位-研究助理

1、具有免疫学、生物信息学、生物学或医学相关研究方向博士学位，在相关领域期刊上以第一作者发表文章，具有国内外一流研究机构博士后研究经历，一般年龄不超过40周岁。

2、协助课题组长进行高水平研究工作，申请课题，并指导实验室成员的研究工作等。

3、熟练掌握以下实验技能者优先考虑：动物实验、流式细胞/分选实验、细胞培养实验及成像相关实验。

4、热爱科研，责任心强，工作积极主动，具有良好的学术道德和团队合作精神，可长期稳定工作。

薪资待遇：

按照上海交通大学医学院以及上海市免疫学研究所有关人事政策，提供事业编制及具有竞争力的薪酬待遇。

招聘岗位-博士后

1、具有免疫学、生物信息学、生物学或医学相关研究方向博士学位，年龄一般不超过35周岁。

2、熟练掌握以下实验技能者优先考虑：动物实验、流式细胞/分选实验、细胞培养实验及成像相关实验。

3、热爱科研，具有独立科研能力，责任心强，善于交流及团队合作。

薪资待遇：

1、提供具有竞争力的待遇，优秀博士后可入选“上海市免疫学研究所博士后创新计划”，年薪27万起。免疫所博士后创新计划实行“3+X” 培养模式，入站3年期满后进行考核，优秀者可继续工作1-2年。

2、鼓励并支持博士后申请各类博士后基金项目和人才计划、上海市“超级博士后”激励计划、“博新计划”（入选者年薪35万起）。

3、为博士后缴纳相关社会保险，申请落户，参照事业编制人员享受体检待遇，享有学校公共资源服务，包括申请上海交通大学医学院博士后公寓或上海市黄浦区公租房等。

申请方式

有意者请将英文个人简历（包括个人基本情况，教育及工作经历，论文发表情况等）发至邮箱: svetoslav_chakarov@shsmu.edu.cn。邮件请注明拟应聘岗位名称。

如果您有任何疑问，请联系徐佳倩老师: 021-63846590-776775。如果您想了解更多信息，请访问我们的实验室网站:https://www.shsmu.edu.cn/sii/info/1053/2084.htm

工作地点：上海市黄浦区重庆南路280号5号楼。

JOIN US

“Myeloid cell biology and metabolism” laboratory directed by Dr. Svetoslav Chakarov in Shanghai Institute of Immunology (SII) at Shanghai Jiao Tong University school of medicine (SJTU-SM) is seeking for highly motivated candidates for Research Assistant, Research Technician and Postdoc Position.

Obesity, defined as excess fat mass, increases risks for multiple metabolic diseases, such as type 2 diabetes, cardiovascular disease and several types of cancer. The obesity epidemic has intensified efforts to understand the mechanisms controlling obesity-induced tissue remodeling. Adipose tissue associated myeloid cells are hypothesized to play central roles in these diseases through their role as inflammatory mediators. In addition to inflammation, myeloid cells perform ‘extra’ tissue-specific functions termed accessory functions. One such putative accessory function is their metabolic activity. However, the role of myeloid metabolism in shaping tissue remodeling during obesity is poorly understood.

The research projects of the lab utilize cutting-edge interdisciplinary research approaches and aim to understand murine and human innate immune cells/stromal cells interactions during obesity and/or metabolic disease. Multiple novel inducible transgenic and gene targeting murine models, genome sequencing analysis, single-cell RNA-seq, single-cell ATAC-seq, Mass Cytometry (CyTOF), “InfinityFlow” pipeline, Imaging Mass Cytometry (IMC), Co-detection by indexing (CODEX) will be involved in the ongoing research projects. Recent work from the lab has been published in journals, such as Science, PNAS, Immunity, Journal of Experimental Medicine. The lab is supported by National Natural Science Foundation of China (NSFC) and was selected into talent programs such as the NSFC National for Excellent Young Scientists Fund Program, Shanghai High-level Overseas Talent Introduction Program, Oriental Scholars of Shanghai Universities Distinguished Professor, Foreign Experts Program of Shanghai Science and Technology Commission and participate in the key project of Ministry of Science Technology "Etiology and epidemic prevention technology system research" as a project backbone.

【Research Assistant】

Successful applicants will have a PhD in Immunology, Biology, or Computational Biology. Have published articles as first author in relevant fields, and have postdoctoral research experience in domestic or foreign first-class research institutions. Can carry out scientific research work independently. Expertise in one of the following areas: Immunology (expertise in innate immunity), Computational biology (basic skills), Biology (Rodent handling, Flow cytometry/cell sorting, tissue/cell cultures and imaging).

Candidates will be responsible for designing, developing and implementing experimental protocols, data analysis and interpretation.

【Postdoc Position】

Successful applicants will have a PhD or MD/PhD in Immunology, Biology, or computational biology, under 35 years old and expertise in one of the following areas: Immunology (expertise in innate immunity), Computational biology (basic skills) For experimental Postdoctoral position: Rodent handling, Flow cytometry/cell sorting, tissue/cell cultures and imaging

Specific projects will be discussed with potential applicants depending on their field of expertise and interests. Projects are centered around several main themes:

Macrophage heterogeneity contribution to obesity and metabolic disease.

Eosinophils crosstalk with their environment during metabolic diseases.

Computational centered tools for integration of single-cell RNA-seq, single-cell ATAC-seq, single-cell protein expression and high dimensional spatial imaging.

Please email your curriculum vitae to svetoslav_chakarov@shsmu.edu.cn.

Please visit our lab website for more details: https://www.shsmu.edu.cn/sii/info/1053/2084.htm

Contact Information:

Tel: 021-63846590*776796

email: svetoslav_chakarov@shsmu.edu.cn

If you have any questions, please don't hesitate to contact teacher Xu Jiaqian: 021-63846590-776775

Salary

Provide competitive remuneration.